Systemic Delivery of Tumor-Targeted p53 Gene Therapy Results in Chemo/Radiosensitization
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چکیده
منابع مشابه
Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA
RNAi technology is taking strong position among the key therapeutic modalities, with dozens of siRNA-based programs entering and successfully progressing through clinical stages of drug development. To further explore potentials of RNAi technology as therapeutics, we engineered and tested VEGFR2 siRNA molecules specifically targeted to tumors through covalently conjugated cyclo(Arg-Gly-Asp-d-Ph...
متن کاملSystemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFv.
BACKGROUND A long-standing goal in genetic therapy for cancer is a systemic gene delivery system that selectively targets tumor cells, including metastases. Here we describe a novel cationic immunolipoplex system that shows high in vivo gene transfer efficiency and anti- tumor efficacy when used for systemic p53 gene therapy of cancer. MATERIALS AND METHODS A cationic immunolipoplex incorpora...
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PURPOSE We recently reported the significant therapeutic efficacy of radioiodine therapy in various tumor mouse models following transcriptionally targeted sodium iodide symporter (NIS) gene transfer. These studies showed the high potential of NIS as a novel diagnostic and therapeutic gene for the treatment of extrathyroidal tumors. As a next crucial step towards clinical application of NIS-med...
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The last two decades have led to a greater understanding of the genetic basis of human malignancy. Although numerous genetic alterations have been detected in cancer, activation of oncogenes and inactivation of cell cycle regulators (e.g., tumor suppressor genes) are now known to play a critical role in the progression of the disease. Therapeutic strategies based on specific molecular alteratio...
متن کاملp53 Tumor Suppressor Gene Therapy for Cancer
Gene therapy has the potential to provide cancer treatments based on novel mechanisms of action with potentially low toxicities. This therapy may provide more effective control of locoregional recurrence in diseases like non–small-cell lung cancer (NSCLC) as well as systemic control of micrometastases. Despite current limitations, retroviral and adenoviral vectors can, in certain circumstances,...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1999
ISSN: 1087-0156,1546-1696
DOI: 10.1038/70147